Omics Technologies

Department

Master's Program Biotechnology

Course unit code

BT_MA20_3_2

Number of ECTS credits allocated

3.0

Name of lecturer(s)

Dr. Weinberger Klaus

Mode of delivery

face-to-face

Recommended optional program components

none

Recommended or required reading

Lesk AM. Introduction to genomics. Oxford University Press 2017
Passos GA. Transcriptomics in health and disease. Springer 2014
Wyatt P. Proteomics - Principles, techniques, and analysis. Syrawood 2018
Sussulini A. Metabolomics: From fundamentals to clinical applications. Springer 2017
Voit EO. A first course in systems biology. Garland Science 2017

Assessment methods and criteria

Course immanent examination

Level of course unit

Master

Year of study

Fall 2025

Semester when the course unit is delivered

3

Language of instruction

English

Learning outcomes of the course unit

In this course, students are familiarised with multiplexed bioanalytical platforms, the so-called omics technologies, the biostatistics and bioinformatics tools needed for managing and analysing the data sets, and the impact of the results on biomarker development and validation. To this end, the course will cover the four major platforms, i.e. genomics, transcriptomics, proteomics, and metabolomics, and evaluate their completeness, standardisation, the qualitative or quantitative nature of the data, the functional annotation of the analytes and, eventually, their relevance for pathobiochemical insights and diagnostic/prognostic tests.

Course contents

- Omics technologies and information flow in systems biology
- Genomics (with a special focus on genetic variability in humans)
- Transcriptomics (array and NGS-based approaches, data visualisation and interpretation)
- Analytical platforms and workflows for proteins and metabolites (NMR, MS)
- Proteomics (top-down and bottom-up, identification and quantitation)
- Metabolomics (targeted and non-targeted, identification and quantitation)
- Biomarker discovery and validation, quality criteria, multi-omics approaches

Planned learning activities and teaching methods

Lecture accompanied by problem-oriented discussions and student's presentations

Work placement(s)

none