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Omics Technologies (BT_MA20_3_2)

Studiengang
  • Masterstudiengang Biotechnologie
Kennzahl der Lehrveranstaltung
  • BT_MA20_3_2
Niveau der Lehrveranstaltung laut Lehrplan
  • Master
Studienjahr
  • Fall 2024
Semester in dem die Lehrveranstaltung angeboten wird
  • 3
Anzahl der zugewiesenen ECTS-Credits
  • 3.0
Name des/der Vortragenden
  • Dr. Weinberger Klaus
Lernergebnisse der Lehrveranstaltung
  • Derzeit nur in Englisch verfügbar
    In this course, students are familiarised with multiplexed bioanalytical platforms, the so-called omics technologies, the biostatistics and bioinformatics tools needed for managing and analysing the data sets, and the impact of the results on biomarker development and validation. To this end, the course will cover the four major platforms, i.e. genomics, transcriptomics, proteomics, and metabolomics, and evaluate their completeness, standardisation, the qualitative or quantitative nature of the data, the functional annotation of the analytes and, eventually, their relevance for pathobiochemical insights and diagnostic/prognostic tests.
Art der Veranstaltung
  • face-to-face
Voraussetzungen laut Lehrplan
  • Derzeit nur in Englisch verfügbar
    MBT
empfohlene optionale Programmeinheiten
  • Derzeit nur in Englisch verfügbar
    none
Lehrinhalte
  • Derzeit nur in Englisch verfügbar
    - Omics technologies and information flow in systems biology
    - Genomics (with a special focus on genetic variability in humans)
    - Transcriptomics (array and NGS-based approaches, data visualisation and interpretation)
    - Analytical platforms and workflows for proteins and metabolites (NMR, MS)
    - Proteomics (top-down and bottom-up, identification and quantitation)
    - Metabolomics (targeted and non-targeted, identification and quantitation)
    - Biomarker discovery and validation, quality criteria, multi-omics approaches
empfohlene Fachliteratur
  • Derzeit nur in Englisch verfügbar
    Lesk AM. Introduction to genomics. Oxford University Press 2017
    Passos GA. Transcriptomics in health and disease. Springer 2014
    Wyatt P. Proteomics - Principles, techniques, and analysis. Syrawood 2018
    Sussulini A. Metabolomics: From fundamentals to clinical applications. Springer 2017
    Voit EO. A first course in systems biology. Garland Science 2017
Lehr- und Lernformen
  • Derzeit nur in Englisch verfügbar
    Lecture accompanied by problem-oriented discussions and student's presentations
Prüfungsmethode
  • Course immanent examination
  • Student's presentations on relevant publications from the omics field focussing on the discussion of their strengths and weaknesses.
Unterrichtssprache
  • English
Praktikum
  • none
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